Differences of the Insulin and Brain Derived Neurotrophic Factor Between Normal Born Weight Baby and Baby With Intrauterine Growth Restriction

Tiyan febriyani lestari; Yusrawati Yusrawati; Arni Amir

doi:10.25077/jom.3.2.103-112.2018

Differences of the Insulin and Brain Derived Neurotrophic Factor Between Normal Born Weight Baby and Baby With Intrauterine Growth Restriction

DOI: https://doi.org/10.25077/jom.3.2.103-112.2018

Author(s)

Tiyan febriyani lestari (Andalas University)
Yusrawati Yusrawati (Andalas University)
Arni Amir (Andalas University)

Abstract

Background: Intrauterine Growth Restriction (IUGR), is a condition in which the fetal growth rate is less than 10 percentiles. Fetal growth is affected by maternal health and nutrition, the hormone insulin and placenta. Placental development is influenced by the Brain Derived Neurotropic Factor (BDNF). Insulin deficiency and BDNF can interfere with fetal development.

Method: This study used an observational research method, with a comparative cross sectional design. The place of research was conducted at Bayangkara Hospital, Dr. Rasidin, TK.III Reksodiwiryo Hospital, and Biomedical Laboratory, Faculty of Medicine, Andalas University. Research time starts from October 2017 to January 2018. The sample of this study was 25 normal babies and 25 babies with IUGR. Insulin levels and BDNF were examined by enzyme-linked immunosorbent assay (ELISA). Test the normality of the data using the Kolmogorov-Smirnov test. Statistical analysis using independent t test.

Results: Insulin levels of 13.2 ± 1.7 mIU / L in infants with normal birth weight and 8.5 ± 1.7 mIU / L in infants born with IUGR (p = 0.000) and BDNF levels 1.5 ± 0.2 ng / ml for infants with normal birth weight and 1.4 ± 0.3 ng / ml in infants born with IUGR (p = 0.008).

Conclusion Insulin levels and BDNF levels of normal birth weight babies are higher than babies born with IUGR.

Keywords

Intrauterine GrowthRestriction(IUGR),Insulin, Brain Derived Neurotropic Factor(BDNF)

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References

Afify, MF. Mohamed, GB. El-Maboud, MA. (2005). Brain-Derived Neurotrophic Factor (BDNF), and Neurotrophin 3 (NT3) Levels in Newborn Cord Sera. Alexandria Journal of Pediatrics, Vol. 19.

Blackburn, ST. 2013). Maternal, Fetal, & Neonatal Physiology : A Clinical Perspective. Elsevier.

Champe, PC. Harvey. RA. Ferrier, DR. (2010). Biokimia Ulasan Bergambar (Edisi 3). Jakarta : EGC.

Christian, LM. Mitchell, AM. Gillespie, SL. Palettas, M. (2016). Serum Brain-Derived Neurotrophic Factor (BDNF) Across Pregnancy and Postpartum: Associations With Race, Depressive Symptoms, and Low Birth Weight. Psychoneuroendocrinology. Vol. 74. pp. 69-76. http://dx.doi.org/10.1016/j.psyneuen.2016.08.025

Cunningham, FG. Leveno, KJ. Bloom, SL. Hauth, JC. Rouse, DJ. Spong, CY. (2013). Obstetri Williams (Edisi. 23,Volume 1). Jakarta. EGC.

Dahlan, MS. (2013). Besar Sampel dan Cara Pengambilan Sampel dalam Penelitian Kedokteran dan Kesehatan (Edisi.3). Selemba Medika.

Dhobale, M. (2013). Neurotrophic Factors and Maternal Nutrition During Pregnancy. Vitamin and Hormones, Vol. 104. ISSN 0083-6729. doi. http://dx.doi.org/10.1016/bs.vh.2016.10.01

Gaccioli, F. & Lager, S. (2016). Placental Nutrient Transport and Intrauterine Growth Restriction. Frontier Physiology. Vol. 7. pp. 40. doi:10.3389/fphys.2016.00040.

Gesteiro, E. Bernal, BR, Bastida, S. Sanchez-Muniz, FJ. (2012). Maternal diets with low healthy eating index or mediterranean diet adherence score are associated with high cord-blood insulin levels and insulin resistance markers at birth. European Journal of Clinical Nutrition. Vol. 66. pp. 1008-1015

Kosim MS, Yunanto A, Dewi R, Sarosa GI, Usman A. (2012). Buku Ajar Neonatologi. Jakarta : Ikatan Dokter Anak Indonesia.

Lee, SH. Zabolotny, JM. Huang, U. Lee, H. Kim, YB. (2016). Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood. Molecular Metabolism. Vol. 5. pp. 589-601. http://dx.doi.org/10.1016/j.molmet.2016.06.011.

Mayeur, S. Silhol, M. Moitrot, E. Barbaux, S. Breton, C. Gabory, A. et al. (2010). Placental BDNF/TrkB Signaling System is Modulated by Fetal Growth Disturbances in Rat and Human. Plasenta. Vol. 31. pp. 785-791. doi:10.1016/j.placenta.2010.06.008.

Panti, AA. Ekele, BA. Nwobodo, EI. Yakubu, A. (2012). The relationship between the weight of the placenta and birth weight of the neonate in a Nigerian Hospital. Nigerian Medical Journal. Vol. 53. doi: 10.4103/0300-1652.103547.

Saifuddin, AB. (2014). Ilmu Kebidanan (Edisi. 4). Jakarta. Bina Pustaka Prawirohardjo.

Sharma, D. Shastri, S. Sharma, P. (2016). Intrauterine Growth Restriction: Antenatal and Postnatal Aspects. Clinical Medicine Insights: Pediatrics. Vol. 10. pp. 67–83. doi: 10.4137/CMPed.s40070.

Sherwood, L. (2011). Fisiologi Manusia dari Sel ke Sistem (Edisi 6). Jakarta. EGC

Wirakusumah F, Mose J, Krisnadi SR, Efendi JS.(2012). Obstetri Fisiologi : Ilmu Kesehatan Reproduksi (Edisi 2). Jakarta: EGC.

Zhang, S. Regnault, RH. Barker, PL. Botting, KJ. McMillen, IC. McMillen, CM. (2015). Placental Adaptations inGrowth Restriction. Nutrients Journal. Vol. 7. pp. 360-389. doi:10.3390/nu7010360.