Differences of Zinc and Copper Levels In Placenta Blood Normal Neonates and Intrauterine Growth Restriction

Melda Amalia; Yusrawati Yusrawati; Rauza Sukma

doi:10.25077/jom.3.2.19-26.2018

Differences of Zinc and Copper Levels In Placenta Blood Normal Neonates and Intrauterine Growth Restriction

DOI: https://doi.org/10.25077/jom.3.2.19-26.2018

Author(s)

Melda Amalia (Andalas University)
Yusrawati Yusrawati (Andalas University)
Rauza Sukma (Andalas University)

Abstract

Zink and copper are the micronutrients which play a role in the growth and development of fetal and infant. Its deficiency in pregnant women shall give a birth the restriction fetal growth ^16,11. This research is proposed to distinguish zinc and copper levels in normal neonates and those restriction fetal growth.

The research was conducted with a comparative cross sectional analysis, experienced by three hospitals those are TK III Reksodiwirjo Hospital, Dr. Rasidin Hospital, and Bayangkara Hospital in the city of Padang. It also conducted in the SMAK Padang Chemistry Laboratory in November 2016 - January 2018. The research sample was taken from newborn blood centers for 60 respondents by consecutive sampling. Zinc and copper levels were examined by Atomic Absorption Spectrophotometry (AAS). Hypothesis testing was done by unpaired t testing.

The results showed the average zinc level in restriction fetal growth group was 89.34 ± 31.53 µg / dL and normal neonates were 122.703 ± 39.3 µg / dL with p = 0.01. The mean copper content in the restriction fetal growth group was 0.5142 ± 0.15 µg / dL and the normal neonate was 0.6892 ± 0.17 µg / dL with p <0.01

The conclusion of this research is zinc and copper levels in normal neonates were significantly higher than neonatal zinc and copper levels restriction fetal growth.

Keywords

Write, no more, than, five, keywords

Full Text:

PDF

References

Almatsier, A. (2009). Prinsip Dasar Ilmu Gizi.Jakarta: PT Gramedia Pustaka Utama.

Anju, S., & Berghella, V. (2013). Intrauterine Growth Restriction (IUGR): Etiology and Diagnosis. Springer, 102-111.

Bermudez, L., Vicent, C. G., Lopez, J., Torro, M. I., & Luber, E. (2015). Assesment of Ten Trace Elements in Umbilical Cord Blood and Maternal Blood: Association with Birth Weight. Journal of Translational Medicine, 13:291.

Elizabeth, K., Krishnan , V., & Vijayakumar, T. (2008). Umbilical Cord Blood Nutrients in Low Birth Weight Babiesin Relation to Birth Weight & Gestational Age. Indian J Med Res, 128-133.

Gernand, A. D., Schulze, K. J., Stewar, C. P., West Jr., K. P., & Christian , P. (2016). Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol, 274-289.

Gibney, M. J. (2009). Gizi Kesehatan Masyarakat.Jakarta: EGC.

Kemenkes RI (2015). Kesehatan Dalam Kerangka Sustainable Development Goals (SDGs).Jakarta : Kementrian Kesehatan RI.

Kemenkes RI. (2015). Situasi Gizi.Jakarta: Infodatin.

Khoushabi, F., Shadan, M. R., & Sharifi-Rad, J. (2016). Determination of Maternal Serum Zinc, Iron, Calcium and Magnesium During Pregnancy in Pregnant Women and Umbilical Cord Blood and Their Association with Outcome of Pregnancy. Mater Sociomed, 104-107.

Linder, M. C. (2010). Biokimia Nutrisi dan Metabolisme (Aminuddin Parakkasi ed.). Jakarta: Universitas Indonesia (UI-Press).

Maamouri, G., Boskabadi, H., Noria, M., Ayatollahi, H., Ghayour-Mobarhan, M., Heshmati, A., et al. (2011). Maternal and Neonatal Zinc and Copper Levels and Birth Weight. Iranian Journal of Neonatology, 26-31.

Ozdemir, U., Gulturk, S., Guvenal, T., Imir, G., & Erselcan, T. (2007). Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood. J.Physiol Biochem, 63-71.

Ross, A. C., Caballero, B., Cousins, J. R., Tucker, K. L., & Ziegler, T. R. (2014). Modern Nutrition in Health and Disease 11th edition.Philadelphia: Lippincott Williams & Wilkins.

Seriana, I., Yusrwati, & Lubis, G. (2015). Hubungan Kadar Zink(Zn) Serum Ibu Hamil Aterm Dengan Beratbadan Lahir Di Rsup Dr. M. Djamil Padang. Jurnal Kesehatan Ilmiah Nasuwakes Vol. 8, 8-14.

Sharma, D., Shastri, S., & Sharma, P. (2016). Intrauterine Growth Restriction: Antenatal and Postnatal Aspects. Libertas Academica, 67.

Soetan, K. O., Olaiya, C. O., & Oyewole, O. E. (2010). The Importance of Mineral Elements for Human, Domestic Animals, and Plants: Review. African Journal of Food Science, 200-222.

Srivastava, S., Mehrotra, P., Srivastava, S., & Siddiqui, M. (2002). Some Essential Elements in Maternal and Cord Blood in Relation to Birth Weight and Gestational Age of the Baby. Biological Trace Element Research, 97-106.

Tsuzuki, S., Morimoto, N., Hosokawa, S., & Matsushita, T. (2013). Associations of Maternal and Neonatal Serum Trace Element Concentrations with Neonatal Birth Weighht. PLOS ONE, 1-5.

UNICEF. (2015). Causes of Deaths among Children Under 5 years.New York: The United Nations Children’s Fund.

Zadrozna, M., Gawlik, M., Nowak, B., Marcinekc, A., Mrowiec, H., Walas, S., et al. (2009). Antioxidants Activities and Concentration of Selenium, Zinc and Copperin. Journal of Trace Elements in Medicine and Biology, 144-149.

Abbas, R. M., Hamdan, Z., Elhassan, m., Hamdan, S. Z., Ali, N. I., & Adam, I. (2014). Zinc and Copper levels in low birth weight deliveries in Medani Hospital, Sudan. BMC Research Note, 1-5.