Rubella Infection In Pregnancy



Joserizal Serudji (Department Obstetric and Gynecology, Medicine Of Faculty, Andalas University, Padang West Sumatra Indonesia)


Rubella is a systemic viral disease that is mild, non-specific, rarely diagnosed, and easily transmitted. Rubella virus easily crosses the placenta, so infection in pregnancy, especially in the first trimester, has the risk of transmitting to the fetus and potentially causing abortion, fetal death, and congenital rubella syndrome (CRS). CRS includes auditory, sensorineural, cardiac, and ocular abnormalities, and is an irreversible congenital disorder. Rubella can be prevented by the administration of antirubella vaccination.

Serology tests are still the most reliable diagnostic test today, although these immune reactions appear later than the appearance of the rash. Analysis of serology test results can provide information on whether you are in acute infection, infected, and are still active, or chronic infection and are currently active or inactive.

Management of rubella infection in pregnancy is symptomatic, nothing can be done for CRS in pregnancy. Postpartum CRS management is multidisciplinary and supportive


Rubella; CRS; Serologic; Diagnosis; Management

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Abdulkadir A and Gebrehiwot TT. Risk Factors for Rubella Transmission in Kuyu District, Ethiopia. I nterdiscip Perspect Infect Dis. 2019 Sep 16;2019.

Bouthry E, Picone O, Hamdi G. Grangeot-Keros L, Ayoubi J-M and Vauloup-Fellous C. Rubella and pregnancy: diagnosis, management and outcomes. Prenatal Diagnosis, Vol 34. December 2014; pp 1246-1253.

George S, Viswanathan R and Sapkal GN. Molecular aspects of the teratogenesis of rubella virus. Biol Res. 2019 Aug 28;52(1):47.

Grant GB, Desai S, Dumolard L, Kretsinger K, Reef SE. Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination - Worldwide, 2000-2018. MMWR Morb Mortal Wkly Rep. 2019 Oct 4;68(39):855-859.

Kurniawan R. Congenital Rubella Syndrome. CDK-274/ vol.46 no. 3 th. 2019.

Lambert N, Strebel P, Orenstein W, Icenogle J and Poland GA. Rubella. Lancet, 2015 June 6; 385(9984):2297-2307.

Lao TT, Hui SYA, Sahota DS. Parity status and the relationship between antenatal rubella serology and obstetric outcome. Sci Rep. 2022; 12: 1278.

Lee H, Kayano T, and Nishiura H. Predicting congenital rubella syndrome in Japan, 2018-2019. Int J Infect Dis. 2019 May;82:1-5.

Mawson AR and Croft AM. Rubella Virus Infection, the Congenital Rubella Syndrome, and the Link to Autism. Int J Environ Res Public Health. 2019 Sep 22;16(19).

Taku NA, Ndze VN, Abernathy E, Hao L, Waku-Kouomou D, Icenogle JP, Wanji S and Akoachere JKT. Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon. PLoS One. 2019 Nov 21;14(11).

Tushabe P, Bwogi J, Abernathy E, Birungi M, Eliku JP, Seguya R, Bukenya H, Namuwulya P, Kakooza P, Suppiah S, Kabaliisa T, Tibanagwa M, Ampaire I, Kisakye A, Bakainaga A, Byabamazima CR, Icenogle JP and Bakamutumaho B1. Descriptive epidemiology of rubella disease and associated virus strains in Uganda. J Med Virol. 2019 Oct 9

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Undergraduate Program of Midwifery
Faculty of Medicine - Universitas Andalas - Indonesia
Faculty of Medicine, Universitas Andalas

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