Email this article Sirenomelia: A Case Report
DOI: https://doi.org/10.25077/jom.7.1.45-50.2022
Author(s)
Joserizal Serudji
(Department Obstetric and Gynecology, Medicine Of Faculty, Andalas University, Padang West Sumatra Indonesia)
Abstract
Sirenomelia is an extremely rare anomaly, an incidence of 1 to 4.2 in 100,000 births, in which a newborn born with legs joined together featuring amermaid-like appearance (head and trunk like humans and tail like fish), and in most cases die shortly after birth. Gastrointestinal and urogenital anomalies and single umbilical artery are clinical outcome of this syndrome. There are two important hypotheses for pathogenesis of mermaidsyndrome: vitelline artery steal hypothesis and defective blastogenesis hypothesis
The cause of the sirenomelia is unknown, but there are some possible factors such as age younger than 20 years and older than 40 years in mother and exposure of fetus to teratogenics. Here, we introduced 39 year old mother’s first neonate with Sirenomelia syndrome. The mother had gestational diabetes mellitus and neonate was born with single lower limb, ambiguous genitalia, and thumb anomalies, and 4 days after birth, the neonate dieddue to multiple anomalies and imperforated anus.Keywords
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Das BB, Rajegowda BK, Bainbridge R, Giampietro PF. Caudal regression syndrome versus sirenomelia: a case report. J Perinatol 2002;22(02):168–170
Duhamel, 1961Duhamel B. From the mermaid to anal imperforation: the syn- drome of caudal regression. Arch Dis Child 1961;36(186): 152–155
Garrido-Allepuz et al., 2011Garrido-Allepuz C, Haro E, González-Lamuño D, Martínez-Frías ML, Bertocchini F, Ros MA. A clinical and experimental overview of sirenomelia: insight into the mechanisms of congenital limb malformations. Dis Model Mech 2011;4(03):289–299.
Moosa et al., 2012Moosa S, Lambie LA, Krause A. Sirenomelia: four further cases with discussion of associated upper limb defects. Clin Dysmor- phol 2012;21(03):124–130
Opitz JM, Zanni G, Reynolds JF Jr, Gilbert-Barness E. Defects of blastogenesis. Am J Med Genet 2002;115(04):269–286
Orioli IM, Amar E, Arteaga-Vazquez J, et al. Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review. Am J Med Genet C Semin Med Genet 2011; 157:358–373
Reddy et al., 2012Reddy KR, Srinivas S, Kumar S, Reddy S, Prasad H, Irfan GM. Sirenomelia: a rare presentation. J Neonatal Surg 2012;1(01):7
Samal SK and and Rathod S. Sirenomelia: The mermaid syndrome: Report of two cases. J Nat Sci Biol Med. 2015 Jan-Jun; 6(1): 264–266.
Sikandar et al., 2009Sikandar R, Munim S. Sirenomelia, the mermaid syndrome: case report and a brief review of literature. J Pak Med Assoc 2009;59 (10):721–723
Taee N, Tarhani F, Goodarzi MF, Safdari M, and Bajelan A. Mermaid Syndrome: A Case Report of a Rare Congenital Anomaly in Full-Term Neonate with Thumb Deformity. AJP Rep. 2018 Oct;8(4):e328-e331.
Taee N, Tarhani F, Safdary A. A case of sirenomelia in newborn of a diabetic mother. Int J Diabetes Metab 2005;5(01):83–87
Taori et al., 2002Taori KB, Mitra K, Ghonga NP, Gandhi RO, Mammen T, Sahu J. Sirenomelia sequence (mermaid): report of three cases. Indian J Radiol Imaging 2002;12(03):399
Verma RP. Genetics of Sirenomelia, the Mermaid Syndrome. Intechopen,February 24th, 2021
Yaşar MZ Yusuf AA, Hassan FM, Ali AA, and Roble MA. Mermaid syndrome: A case report in Somalia. Ann Med Surg (Lond). 2022 Apr; 76: 103533.
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Copyright (c) 2022 Joserizal Serudji
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Undergraduate Program of Midwifery
Faculty of Medicine - Universitas Andalas - Indonesia
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.