Antioxidant supplementation during in vitro maturation

Amalia Ratna Kusumaningrum

doi:10.25077/jom.4.2.1-7.2019

Antioxidant supplementation during in vitro maturation

DOI: https://doi.org/10.25077/jom.4.2.1-7.2019

Author(s)

Amalia Ratna Kusumaningrum (Master of Reproductive Health, Faculty of Medicine Airlangga University, Prof Moestopo Street 47, Surabaya 60132, Indonesia)

Abstract

During in vitro maturation (IVM), oocytes are exposed to different situations from in vivo which may cause oxidative stress. Supplementation of antioxidants to the culture media is effective in as antioxidant defences against reactive oxygen species (ROS). Antioxidant is safe, it has some side effects. This is reviewed in this paper. Studies reported, supplementation antioxidant with different dose showed different effects. Double-edged eﬀects of exogenous antioxidants on cellular responses during in vitro maturation depending potentially on their concentrations. Physiologic doses leading to beneficial eﬀects whereas high doses may result in harmful eﬀects.

Keywords

Antioxidant, in vitro maturation, infertility, oocyte, reactive oxygen species (ROS)

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