Relationship of Ferritin Levels of Pregnant Women Who Had Fe Deficiency Anemia with Ferritin Levels and APGAR of the Neonates

Zuliyana Zuliyana; Yanwirasti Yanwirasti; Roza Sri Yanti

doi:10.25077/jom.3.2.137-145.2018

Relationship of Ferritin Levels of Pregnant Women Who Had Fe Deficiency Anemia with Ferritin Levels and APGAR of the Neonates

DOI: http://dx.doi.org/10.25077/jom.3.2.137-145.2018

Author(s)

Zuliyana Zuliyana (Andalas University)
Yanwirasti Yanwirasti (Andalas Universitas)
Roza Sri Yanti (Andalas University)

Abstract

Iron deficiency anemia in pregnant women can have a negative impact on the baby, such as placental development, low birth weight, prematurity, baby health, hypoxia, decreased immune status, possibility of having physiological disorders and infant growth. The aim of this study was to determine the relationship of ferritin levels of pregnant women who had Fe deficiency anemia with ferritin levels and Apgarof the neonates.This was a cross sectional study in the population of pregnant women who had Fe deficiency anemia and neonates who met the inclusion criteria taken by consecutive sampling technique in the working area of Lubuk Buaya Health Center, Ambacang Health Center and Ikur Koto Health Center. Examination of ferritin levels was carried out in the Biomedical Laboratory of Faculty of Medicine, Andalas University using ELISA method. Data were analyzed by Pearson Test and Mann-Whitney Test. The results of this study showed there was no significant relationship between maternal ferritin levels on neonatal ferritin r = 0.248, p = 0.204. It also showed that there was no relationship between maternal ferritin levels on APGAR p value = 0.199 and there was a significant relationship between neonatal ferritin levels on APGAR p value = 0.002. The conclusion of this study is that there was a positive relationship between maternal ferritin levels with neonatal ferritin levels, there was no significant relationship between maternal ferritin levels and APGAR score, there is a significant relationship betweenneonatal ferritin levels with APGAR score. By improving nutrition, socioeconomic, qualitative antenatal care, early referral of risky cases and iron supplementation can reduce the incidence of anemia.

Keywords

Anemia, Ferritin, APGAR

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References

Ani, LS. (2013). Anemia Defisiensi besi : masa prahamil dan hamil. Jakarta : EGC.

Briawan, D. (2013). Anemia : masalah gizi pada remaja wanita. Jakarta : EGC

Breymann, C. Honegger, C. Holzgreve, W. Surbek, D. (2010). Diagnosis and Treatment of Iron-deficiency anaemia during pregnancy and postpartum. Arch Gynecology Obstetrics. vol. 282. pp. 577-580. doi:10.1007/s00404-010-1532-z

Kementerian Kesehatan RI. (2015). Profil Kesehatan Indonesia Tahun 2014. Jakarta : Kementerian Kesehatan RI.

Pontoh, S. Mayulu, N. Engka, JN. (2015). Hubungan Kadar Ferritin dan Asupan Protein Pada Ibu Hamil Trimester II-III di Kabupaten Bolaang Mongondow Utara. Jurnal e-Biomedik (eBm).vol. 3. no. 3. pp. 770-776.

Handini, PSN. (2010). Hubungan Anemia Gravidarum pada Kehamilan Aterm dengan Asfiksia Neonaturum di RSUD Dr. Moewardi Surakarta. Skripsi. Universitas Sebelas Maret. Surakarta.

Lissauer, T. Fanaroff, AA. (2009). At a Glance Neonatologi. (Alih Bahasa: Vidhia Umami). Jakarta : Erlangga

Laflamme, EM. (2010). Maternal Hemoglobin Concentration and Pregnancy Outcome : A Study of the Effects of Elevation in El Alto, Bolivia. MJM 2010 : 13 (1): 47-55.

Hussain, MAM. Gaafar, TH. Laulicht,M. Hoffbrand, AV. (1977). Relation of Maternal and Cord Blood Serum Ferritin. Archives of Disease in Childhood. vol. 52. pp. 782-784.

Paiva, A. Rondo, P. Pagliusi, R. Latorre, M. Cardoso, M. Gondim, S. (2007). Relationship between the iron status of pregnant women and their newborns. Rev Saude Publica. vol 41. no. 3.

Wibowo N,Regina Purba RT. Anemia Defisiensi Besi dalam Kehamilan. Dexa Media, Jan-Maret 2006; 19(1).

Estrada Jose A, contreras Irazu, Rivero F Bernardo Pliego, Otero Gloria A. (2014) : Review Molecular mechanisms of cognitive impairment in iron deficiency: Alterations in brain derived neurotrophic factor and insulin like growth factor expression and function in the central nervous system, Nutritional Neuroscience, vol 17 no 5.

Lozoff Betsy, MD and Georgieff Michael K MD. (2006) : Iron deficiency and brain development, Seminar in Pediatric Neurology; 13: 158-165

Knovich, M. A. (2009). Ferritin for the Clinician. National Institute of Health, 23(5), 95-104.

Akhter, S. Momen, MA. Rahman, NC. Rahman SD, Karim, RE. Selim, S. Et al. (2014). Maternal Anemia and its Correlation with Iron status of Newborn. Birdem Medical Journal. vol. 4. no. 1

Shao, J. Lou, J. Rao, R. Georgieff, MK. Kaciroti, N. Felt, BT. et al. (2012). Maternal Serum Ferritin Concentration is Positively Associated withNewborn Iron Stores inWomen with Low Ferritin Status in Late Pregnancy. J. Nutr. vol 142. ed. 11.pp 2004-2009

Terefe, B. Birhanu,A. Nigussie, P. Tsegaye, A. (2015). Effect of Maternal IronDeficiency anemia on the Iron Store of Newborns in Ethiopia. Hindawi Publishing Corpotion Anemia. vol 2015. pp. 6

Lao, TT; Tam KF; Chan, LY. (2010). Third trimester Iron Status and Pregnansy Outcomes in Non-ananemic Women; Pregnancy Unfavourably Affected by Maternal Iron Excess. Human Reproduction.Vol 15 no.8 pp.1843-48.

Dane, Banu; Arslan, Necmi; Batmaz, Gonca; and Dane, Cem. (2013). Does maternal anemia affect the newborn?Özgün Araştırma.pp.195-199.

Breymann C, Bian XM, Blanco-Capito LR, ChongC, Mahmud G, Rehman R. Expert recommendations for the diagnosis and treatment of iron-deficiency anemia during regnancy and the postpartum period in the Asia-Pacific region. Perinat Med 2011; 39: 113-121.

Ren A, Wang J, Ye RW, Li S, Liu JM, Li Z. Low first-trimester hemoglobin and low birth weight, preterm birth and small for gestational age newborns. Int J Gynaecol Obstet 2007; 98: 124-128.

Levy A, Fraser D, Katz M, Mazor M, Sheiner E. Maternal anemia during pregnancy is an independent risk factor for lowbirthweight and preterm delivery. Eur J Obstet Gynecol Reprod Biol 2005; 122: 182-186.

Francis, S. & Nayak, S., 2013. Maternal Haemoglobin Level and Its Association with Pregnancy Outcome among Mothers. Nitter University Journal of Health Science, 3(3): 96-100.

Lee, ACC; Mullany, LC; Tielsch, JM; Katz, J; Khatry, SB; LeClerq, SC; et al. (2008). Risk Factors for Neonatal Mortality due to Birth Asphyxia in Southern Nepal. Pediatrics.vol. 121(5). pp.1381-90.

Nayeri, F; Shariat, M; Dalili, H; Adam, LB; Mehrjerdi, FZ; Shakeri, A. (2012). Perinatal risk factors for neonatal asphyxia in Vali-e-Asr hospital, Tehran-Iran. Iran J Reprod Med. Vol. 10. No.2. pp: 137-140.

Arisman. (2009). Gizi dalam daur kehidupan : buku ajar ilmu gizi (Edisi 2). Jakarta : EGC.

Al-Hilli, NM. (2010). The Effect of Maternal Anemia on Cord Blood Haemoglobin and Newborn Birth weight. Karbala Journal of Medicine. Vol. 2. No. 8-9.

Koura, GK; Ouedraogo, S; Le Port, A; Watier, L; Cottrell, G; Guerra, J; et al. (2012). Anaemia during pregnancy:impact on birth outcome and infanthaemoglobin level during the first 18 months of life. Tropical Medicine and International Health. volume 17 no 3 pp 283–291.

Lee, HS. Kim, MS. Kim, MH., Kim, YJ. Kim, WY. (2006). Iron status and its association with pregnancy outcome in Korean pregnant women. European Journal of Clinical Nutrition. vol. 60. pp.1130-1135