Relationship Between Maternal And Fetal Resistin Levels in Obesity nnd Normal to Anthropometry Newborn Babies

Siska Anggraini; Yusrawati Yusrawati; Mayetti Mayetti

doi:10.25077/jom.3.2.84-93.2018

Relationship Between Maternal And Fetal Resistin Levels in Obesity nnd Normal to Anthropometry Newborn Babies

DOI: http://dx.doi.org/10.25077/jom.3.2.84-93.2018

Author(s)

Siska Anggraini
Yusrawati Yusrawati (Obstetri Gynecology,RSUP DR M. Djamil,Faculty of Medicine)
Mayetti Mayetti (Sub Division Emergency Child Hospitalization,RSUP DR. M. Djamil , Faculty of Medicine)

Abstract

Status of excess nutrition (obesity) and less influence on fetal growth. Obesity has increased fat, which increases some adipokines, one of which is resistant. Resistin plays a role in maintaining glucose homeostasis by inducing insulin resistance, antiadipogensis and inflammation. Resistin is found in the baby's umbilical cord so that resistin can play a role in fetal growth. The purpose of this study was to evaluate differences in maternal resistin levels between obese and normal weight mothers and their relationship to anthropometry of newborns. Material and Matode: This research is an observational analytic study with cross-sectional design. Subjects consisted of 20 obese mothers and 20 normal weight people. Sampling was done by consecutive sampling at Dr. M. Djamil Padang, dr. Rasidin Padang and TK III Reksodiwiryo Padang Hospital, Indonesia. Blood samples were measured by spectrophotometry. Statistics were analyzed by Mann Whitney U-Test and Spearman Test. Results: Median maternal resistin in obese subjects and normal weight was 1406 (1024.31-1947.78) ng / L and 1308.46 (740.16-1521.56) ng / L (p <0.05). Median fetal resistin in obese subjects and normal weight was 1086.47 (820.09-2205.29) ng / L and 1077.59 (704.65-1654.76) ng / L (p> 0.05). Conclusion: There was a relationship between maternal resistin and newborn body weight with r = -0.412 (p <0.05). There was a correlation between fetal resistin levels with the weight of newborns and infant body length (r = -0.694, and r = -0.455) (p <0.05). Resistin levels affect fetal weight gain in the obese and normal weight.

Keywords

Maternal Resistin, Fetal Resistin, Anthropometry of Newborn, Obesity

Full Text:

PDF

References

Avagliano, L. Garo, C. And Marconi, AM, 2012. Placental Amino Acids Transport In Intrauterine Growth Restriction. Journal Of Pregnancy. Vol. 2012.pp 6.

Benomar, Y. Gertler, A. De Lacy, P. Crepin, D. Hamouda, HO. Roffault, L. et al, 2013. Central Resistin Overexpossure induces insuli resistance through Toll-Like 4 Receptor Diabetes Journal. Vol. 62. pp. 102-144.

Blackburn, ST. 2013. Maternal, Fetal & Neonatal Physiology : A Clinical Perspective. Elsevier.

Buller, CL, 2010. Role Of GLUT1 In The Mammalian Target Of Rapamycin Pathway: Machanism Of Regulation.Dissertation. Molecular and Integrative Physiology University. Michigan.

Challier,JC.Basu, S. Bintein, T. Hotmire, K. Minium, J. Catalano, PM. et al, 2008. Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta. National Institute Of Health.Vol. 29, no. pp. 274-281.

Cortelazzi, D. Corbetta, S. Ronzoni, S. Pelle, F. Marconi, A. Cozzi, V. et al, 2008. Maternal And FoetalResistin and adiponecin Concentrations In Normal nad Complicated Pregnancies. Clinical Endocrinology Queen’s Medical Research Institute. Vol. 66. pp. 447-453.

Danqing, C. Minyue, D. Qin, F. Jing, HE. Zhengping, W. Xiaofu, Y, 2005. Alterations of serum resistin in normal pregnancy and pre-eclampsia. Clinical Science. Vol. 108. Pp. 81-84.

Farid, SD. Najati, N. Gharebaghi, MM. Haghjo, AG. Ghojazadeh M, 2012. Resistin in Cord Blood of Small for Gestation Age and Appropriate for GestationAge Term Neonates. Tehran University Of Medical Science. Vol. 23, no.6. pp 659-663.

Lissauer T &fanaroff A. 2009. At a Glance Neonatologi. Erlangga. Jakarta.

Fatouhikia, S. Pourarian, S. Javanmardi, H. Setoodehnia, Z andSaki, F, 2016. Investigating the Association of Cord Blood Resistin and Birth Weight in Term and Preterm Neonates. Journal OfPediatrica. Vol.4(11).pp.3769-75.

Fernandez, CM. Acro, AD. Gallardo, N. Aguado, L. Rodriguez, M. Ros, M. et al, 2013. S-Resistin Inhibits Adipocyte Diffrentiation And Increase TNFα Expression And Secretion In 3T3-L1 Cells. BiochimicaEtBiophysicaActa. Vol. 1803. pp. 1131-1141.

Fitter, S. Matthews, M.P. Martin, SK. Jianling, X. Soo, S.O. Walkley, C.R. et al, 2016. mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation. American Society For Microbiology.Vol. 37.

Geum, JC. Sang, WY. Soon, CH. Min-Jeong, OH. Tak, K. Hai, JK. Etal, 2006. Correlations between umbilical and maternal serum resistin levels and neonatal birth weight. Acta Obstetriaet Gynecologica. Vol 85. Pp. 1051-1056.

Gilbert, L. Xiaofei, H. Farmer, P. Boden, S. Kozlowski, M. Rubin, J. et al, 2000. Inhibition Of Osteoblast Differentation By Tumor Necrosis Factor-α. The Endocrinology Society.Vol.141, no. 11

Gaccioli F, Lager S, Powell T, and Jansson T, 2013. Placental Transport in Response to Altered Maternal Nutrition. National Institute Of Health. Vol. 4, no. 2. pp. 101-115

Huanbin, H. Liping, X. Aimei, W. Jiashi, G. Huihui, K. Yungzhong, Y. Xiaoning, Y, 2016. Correlation of resistin expression in maternal serum and subcutaneous adipose tissue with insulin resistance in gestational diabetes mellitus. Original Article.Vol. 9. No. 9. pp. 18721-18727.

Hyeong, KP and Ahima, RS, 2013. Resistin in Rodents and Humans. RevieObesity and Metabolic syndrome. Diabetic Metabolic Journal Seoul. Vol. 37. pp.404-414.

Jing, W. Li-Xin, S. Xing, D. Xin, W. Nan, W. Shu-se, W, 2010. Relationship of adiponectin and resistinlevels in umbilical serum, maternal serum and placenta with neonatal birth weight. Australian And New Zealand Journal Of Obstetrica And Gynecology.Vol.50.pp. 432-438.

Jyh, KN. Shali, MT. Romero, R. Kusanovic, JP. Erez, O. Gotsch, F. et al, 2007. Resistin : A Hormone Which Induces Insuli Resistance Is Increased In Normal Pregnancy. Perinatology Research. Vol. 35. pp. 513-512.

Karatas, A. Issikent, NT. Ozlu, T and Demirin, H, 2014. Relationship of maternal serum resistin and visfatin levels with gestational diabetes mellitus. Gynecological Endocrinology.Vol.30(5).pp. 1473-0766.

KementrianKesehatan Indonesia tahun 2015 “RenstraKesehatan Indonesia 2015-2019”Jakarta.

Marfianti, E, 2006. Perbedaan Kadar Resistin Pada Obes Dengan Resistensi Insulin Dan Obes Tanpa Resistensi Insulin. Jurnal Kedokteran Dan Kesehatan Indonesia.

Megia, A. Vandrell, J. Gutierrez, C. Sabate, M. Brosch, M. Fernandez-Real, JM. et al, 2008. Insulin Sensitivity and Resistin Levels In Gestational Diabetes Mellitus And After Parturition. European Journal Of Endocrinology. Vol. 158. pp. 173-178.

Norwood, AK, 2013. Maternal Obesity Alters Fetal Development Due To Impaired Placental Function And Has Lasting Effects On Adult Offspring. Thesis. University Of Nebraska. Nebraska.

Noureldeen, A.F. Qusti, S.Y. And Al-seeni. M, 2014. Serum Leptin, Adiponectin, Resistin, Visfatin and Inflammatory Cytokines in Normal Weight and Obese Women with Normal Pregnancy and with Preeclampsia. Life Science Journal.Vol. 11. No. 5.

Pak-Cheng, NG. Cheuk, L. Christopher,WK. Lam, I. Chan, EW. Tai, F. et al, 2006. Resistin in Preterm and Term Newborns: Relation to Anthropometry, Leptin, and Insulin. Pediatric Research. Vol 58. No.4.

Hehai, P. Xiang, L. Jianru, W. Kuibo, Z. Hao, Y. Zerni, L, 2015. LIM Mineralization Protein-1 Enhances Bone Morphogenetic Protein-2–Mediated Osteogenesis Through Activation of ERK1/2 MAPK Pathway and Upregulation of Runx2 Transactivity. JounrnalOf Bone And Mineral Research.Vol 30. No. 8. Pp 1523-1535.

Robert, K.A. Riley, S.C. Reynolds, R.M. Barr, S. Evans, M. Statham, A. et al, 2011. Placental Structure And Inflammation In Pregnancies Associated With Obesity. Elsevier Journal. Vol. 32. Pp. 247-254.

Sadler, TW. (2012). Embriologi Kedokteran Langman. Edisi 12. Jakarta: EGC.30.Shaw, J.E. Zimmet, P.Z.Courteen, M.D. Dowsw, G.K. Chitson, P, 1999. Impaired Fasting Glucose Or Impaired Glucose Tolerance. Epidemiology/Health Service/Psychosocial Research. Vol. 22. Pp. 399-402.

Simon, ND. Nicuolo, FD. Marzioni, D. Castellucci, M. Sanguinetti, M. D’lppolto,S. et al,2009. Resistin modulates glucose uptake and glucose transporter-1 (GLUT-1) expression in trophoblast cells. Blackwell Cellular and Molecular Medicine.Vol. 1, no. 2. pp. 388-397.

Un, JJ and Myung-Sook, C, 2015. Obesity And Its Metabolic complications: The Role Of Adipokines And The Relationship Between Obesity, Inflammation, Insulin Resistance, Dyslipidemia And Nonalcoholic Fatty Liver Disease. Center For Food And Nutritional Genomic Reserach. Vol. 15. pp. 6184-6223.

Unwin, N. Shaw, J. Zimmet,P. Alberti, K.G, 2002. Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. International Diabetes Federation IGT/IFG Consensus Statement. Report of an Expert Consensus Workshop 1–4 August 2001, Stoke Poges, UK

Vernini, JM. Moreli, JB. Antonio, R. Negrato, CA. Cunha, MV. Caldero, IM, 2016. Maternal AdipokinesAnd Insulin As Biomakers Of Pregnancy Complicated By Overweight And Obesity. Diabetology& Metabolic Syndrome.Vol. 8. Pp.68.

Viengsakhone, L. Yoshida, Y. Or-Rashid, H & Sakamoto, J, 2010. “ Factors Affecting Low Birth Weight” At Four Central Hospitals In Vientine, Lao Pdr, Journal Nagoya med Vol. 72, pp. 51-58.

Yuan, L. Cheng-Yuan, S. Shan-Shan,W. Qiu-Hua, L. Ling-Qing, Y. Er-Yuan,L, 2013. Novel AdipokinesAnd Bone Metabolism.

Yoshito, I. Hiroyuki, T. Susuma, H. Kazuaki, K and Kentaro, K, 2013. Resistin Affects Lipid Metabolism During Adipocyte Maturation Of 3T3-L1 Cells. Departments Of Medicine And Oncological Sciences. Vol. 280.pp.5884-5895.