Anticonvulsant for preeclampsia: Magnesium sulfate or Diazepam ?

Joserizal Serudji

doi:10.25077/jom.7.2.51-58.2022

Anticonvulsant for preeclampsia: Magnesium sulfate or Diazepam ?

DOI: https://doi.org/10.25077/jom.7.2.51-58.2022

Author(s)

Joserizal Serudji (Department Obstetric and Gynecology, Medicine Of Faculty, Andalas University, Padang West Sumatra Indonesia)

Abstract

Preeclampsia is a multisystem disorder which is still the leading cause of maternal death today. The occurrence of seizures in preeclampsia (eclampsia) increases the risk of maternal and perinatal morbidity and mortality. Therefore, seizure in preeclampsia should be prevented and should be managed accurateely.

The standard therapy for managing severe preeclampsia/eclampsia is the use of an anticonvulsant that is aimed to prevent/stop seizures, prevent the recurrence of attacks, to minimize and to manage their complications, and optimize the time for the birth of the baby. On the other hand, the selection of anticonvulsants needed is still controversial, so debates and studies on the effectiveness between each anticonvulsant are necessary.

Comparative research between magnesium sulfate and diazepam is widely carried out, both retrospective and prospective. Magnesium sulfate is more effective than diazepam, especially in terms of overcoming seizures, and suppressing maternal mortality and perinatal morbidity, so the choice of magnesium sulfate over diazepam is more realistic.

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References

Abalos E, Cuesta C, Grosso AL, Chou D and Say L, 2013. Global and Regional Estimates of Preeclampsia and Eclampsia: A Systematic Review. EJOG 2013, Sept. Vol 170, pp 1-7.

Duley L, Henderson-Smart DJ, Walker GJA, Chou D. Magnesium sulphate versus diazepam for eclampsia (Review). The Cochrane Library. 2010, Issue 12

Ikramullah K, Ambreen and Humera. Magnesium Sulfate Versus Diazepam Infusion in Eclampsia. ANNALS VOL 15. NO. 3 JUL. - SEPT. 2009

Jeyabalan A, 2013. Epidemiology of preeclampsia: Impact of obesity. Nutr Rev. 2013 Oct; 71(0 1).

Kassie GM, Negussie D, Ahmed JH. Maternal outcomes of magnesium sulphate and diazepam use in women with severe pre-eclampsia and eclampsia in Ethiopia. Pharmacy Practice 2014a Apr-Jun;12(2):400.

Kassiea GM, Negussieb D and Ahmedc JH. Perinatal Outcomes of Magnesium sulphate and Diazepam use in Severe Pre-eclamptic and Eclamptic Mothers, Jimma University Specialized Hospital, Southwest Ethiopia Gizat. International Journal of Sciences: Basic and Applied Research (IJSBAR)(2014b) Volume 13, No 1, pp 426-436

Lidapraja HS, Manoe IMSM dan Surya IGP, 2011. Profil Penderia Hipertensi dalam Kehamilan di RSU Sanglah Denpasar dan RS dr. Wahidin Sudirohusodo makasar. Research Gate, Juli 2011.

Negussieb D and Ahmed JH. Perinatal Outcomes of Magnesium sulphate and Diazepam use in Severe Pre-eclamptic and Eclamptic Mothers. International Journal of Sciences: Basic and Applied Research (IJSBAR)(2014) Volume 13, No 1, pp 426-436

Ofutet EO, Mfem CC, Okpo-ene IA and Agu CE. Comparative Effect of Two Anticonvulsants (Magnesium Sulphate and Diazepam) on 4-Aminopyridine - Induced Seizures in CD1 Mice. Saudi J. Biomed. Res.; Vol-1, Iss-2(Jun-Aug, 2016):42-47

Osungbade KO and Ige OK, 2011. Public Health Perspectives of Preeclampsia in Developing Countries: Implication for Helath Services Strengthening. J. pregnancy 2011, Apr.

Prevalensi Preeklampsia Berat di Rumah Skit Ciptomangunkusumo. Perpustakaan Fakultas Kedokteran UI. 2014.

The Eclampsia Trial Collaborative Group. Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet 1995; 345: 1455-63.