Correlation of ApoE Gene Polymorphism with Coronary Heart Disease Severity in Patients with Acute Coronary Syndrome Who Receive Statin Therapy, Padang, Indonesia



DOI: https://doi.org/10.25077/jom.7.1.1-7.2022


Author(s)

Elly Usman (Department of Pharmacology and Therapeutics, Faculty of Medicine, Andalas University) Orcid ID
Gestina Aliska (Department of Pharmacology and Therapeutics, Faculty of Medicine, Andalas University)
Masrul Syafri (Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia)

Abstract


Coronary Heart Disease (CHD) is still the most common cause of death. Ischemic heart disease causes more than 7 million (12.8%) deaths worldwide. It is estimated that 3,750,000 Indonesians have CHD. CHD is a disease with many risk factors. ApoE gene polymorphism is associated with atherosclerosis and plays a role in lipid metabolism, which is 2-16% affecting variability in LDL levels. This study aims to look at the relationship between ApoE gene polymorphism and the severity of coronary heart disease. Data regarding ApoE gene polymorphism was obtained using polymerase chain reaction (PCR). DNA was isolated from white blood cells using DNA purification kit. ApoE2, ApoE3, ApoE4 alleles were detected by DNA sequencing. Data on the severity of coronary heart disease were obtained from angiography and were calculated based on SYNTAX scores. In this study, ApoE was obtained with e2 allele frequencies (4.63%), e3 (78.70%), and e4 (16.67%) with E2 / 2 (0%), E2 / 3 (3.70%), E2 / 4 (5.56%), E3 / 3 (64.81%), E3 / 4 (24.07%), and E4 / 4 (1.85%). The relationship between the SYNTAX score and the ApoE genotype has no significant difference. ApoE3 / 4 genotype has the highest SYNTAX score and the e4 allele has the most influence on CHD despite the influence of statin therapy.

Keywords


Coronary heart disease, apolipoprotein, SYNTAX score

Full Text:

PDF

References


A. Go, D. Mozaffarian, V. Roger, E. Benjamin, J. Berry, W. Borden, et al, “Heart disease and stroke statistics--2013 update : a report from the American Heart Association”, Circulation, 2013, 127, pp. e6–245.

Badan Penelitian dan Pengembangan Kesehatan, “Riset Kesehatan Dasar (RISKESDAS) 2013”, Lap Nas 2013, 2013, pp. 1-384.

C.D. Mathers, D. Loncar, “Projections of global mortality and burden of disease from 2002 to 2030”, PLoS Med, 2006, 3(11), pp. 2011-2030.

G. Sianos, M.A. Morel, A.P. Kappetein, M.C. Morice, A. Colombo, K. Dawkins, M. van den Brand, N. Van Dyck, M.E. Russell, F.W. Mohr, P.W. Serruys, “The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease”, EuroIntervention, 2005, 1(2), pp. 219-27.

H. Xu, H. Li, J. Liu, D. Zhu, Z. Wang, A. Chen, et al, “Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction”, PLoS One, 2014, 9(8), pp. e104608.

I. Elmadbouh, Y. Elghobashy, E. Abd-Allah, A. Reda, A. Fathe, S. Tayel, T. Abd-Elhakim, “Relationship of apolipoprotein E polymorphism with lipid profiles in atherosclerotic coronary artery disease”, The Egyptian Heart Journal, 2013, 65, pp. 71–78.

M.N. Haan, R.M. Elizabeth, “Apolipoprotein E Genotype and Cardiovascular Diseases in the Elderly”, Curr Cardio Risk Rep, 2010, 4, pp. 361 – 368.

PERKI, “Pedoman tata laksana sindrom koroner akut, perhimpunan dokter spesialis kardiovaskular Indonesia”, Centra Communications, 2015, 1, pp. 11-35.

P.S. Hauser, V. Narayanaswami, R.O. Ryan, “Apolipoprotein E: from lipid transport to neurobiology”, Prog Lipid Res, 2011, 50(1), 62-74.

S. Ng , S. Soerianata , H. Andriantoro, J.P. Ottervanger, D.E. Grobbee, “Timing of coronary collateral appearance during ST-elevation myocardial infarction”, Interv Cardiol, 2012, 4(1), pp. 137–43.

Y. Song, M.J. Stampfer, S. Liu, “Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease”, Annals of Internal Medicine, 2004, 141, pp. 137–147


Article Metrics

This article has been read : 135 times
PDF file viewed/downloaded : 47 times

Copyright & License


Copyright (c) 2022 Elly Usman

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Published by:
Undergraduate Program of Midwifery
Faculty of Medicine - Universitas Andalas - Indonesia
Faculty of Medicine, Universitas Andalas

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.